POSTOPERATIVE PULMONARY INSUFFICIENCY AFTER OPEN HEART SURGERY AND CHANGES IN PULMONARY SURFACE ACTIVITY

DOI Web Site Web Site PubMed

この論文をさがす

説明

Concerning the relationship between the disturbance in pulmonary function after open heart surgery and changes in alveolar surface activity, the results of experimental and clinical studies are described. 1. In some patients with cardiac disease, the minimal surface tension was already slightly elevated before surgery. After operation, the markedly high value of 11.0 dynes/cm on the average was temporally obtained. 2. For the determination of surface tension measurement at 37°C is more profitable. 3. After I hour of complete extracorporeal circulation, the surface activity markedly fell, but a considerable decrease was noted even after simple thoracotomy. 4. After 24hours of IPPB, no remarkable change was seen in minimal surface tension. After 48 hours of IPPB, the markedly high value of 13.6 dynes/cm on the average was obtained. 5. The inhalation of lecithin through a nebulizer during IPPB improved the decreased pulmonary compliance and PaO2 to some extent. 6. By the intravenous drip infusion of CDP-choline from immediately before the operation, throughout the operation to the postoperative period, a marked result on the maintenance of alveolar surface activity was achieved. The mechanism in the development of post-operative pulmonary insufficiency after open heart surgery, the influence of extracorporeal circulation and long term IPPB on pulmonary function, and the essence of preventive measures and postoperative management have been dis-cussed in outline.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ