Strophanthin-G Toxicity and Sodium Ions

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Strophanthin-G toxicity was tested in isolated guinea-pig atria, in vitro. The toxicity was figured out by measuring the time required to arrest spontaneous atrial contraction in a medium in which concentrations of inorganic ions were modified and by estimating the potassium and sodium contents in atria having suffered a toxic dose of strophanthin-G. The toxicity was markedly lessened by a medium containing a low concentration of sodium chloride or by the presence of trimetazidine. The action of trimetazidine on strophanthin-G in atria has been discussed.

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