Digitalis

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  • Kunimoto Satoshi
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine

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  • ジギタリス製剤

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Although digitalis has been among the most commonly prescribed drugs for the treatment of heart failure for a long time, the DIG trial indicated that digitalis did not reduce the overall mortality and cardiovascular death. However, it did reduce the rate of hospitalization both overall and for worsening heart failure. Digitalis is also effective for control of heart rate at rest, but not during exercise. By contrast, as its efficacy depends on the positive inotropic activity, digitalis is effective for control of the heart rate at rest in patients with atrial fibrillation with heart failure, LV dysfunction, or for underlying disease. In combination with a β-blocker, either may be effective in patients with or without heart failure. These findings define more precisely the role of digitalis in the management of chronic heart failure and atrial fibrillation.

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