Transient Improvement of the Quality-of-Life after Irinotecan Hydrochloride Therapy in a Child with Relapsed Ewing Sarcoma Family of Tumor

DOI Web Site Web Site 8 References
  • Shichino Hiroyuki
    Divisions of 1) Pediatrics and Child Health, Nihon University School of Medicine
  • Chin Motoaki
    Divisions of 1) Pediatrics and Child Health, Nihon University School of Medicine
  • Ryo Naohiro
    Divisions of 1) Pediatrics and Child Health, Nihon University School of Medicine
  • Yoshida Yukihiro
    Divisions of Orthopedic Surgery, Nihon University School of Medicine
  • Saitou Tsutomu
    Divisions of Radiology, Nihon University School of Medicine
  • Mugishima Hideo
    Divisions of 1) Pediatrics and Child Health, Nihon University School of Medicine

Bibliographic Information

Other Title
  • 塩酸イリノテカンにより一時的に生活の質の改善がみられた再発ユーイング肉腫ファミリー腫瘍の一小児例
  • 症例報告 塩酸イリノテカンにより一時的に生活の質の改善がみられた再発ユーイング肉腫ファミリー腫瘍の一小児例
  • ショウレイ ホウコク エンサン イリノテカン ニ ヨリ イチジテキ ニ セイカツ ノ シツ ノ カイゼン ガ ミラレタ サイハツ ユーイング ニクシュ ファミリー シュヨウ ノ イチ ショウニレイ

Search this article

Abstract

The prognosis of relapsed Ewing sarcoma family of tumor (ESFT) continues to be miserable. In such cases, the purpose of treatment should be palliative care. We report a case of a boy with relapsed EFST who was treated with irinotecan hydrochloride. This treatment was able to provide him with a transient improvement of quality of life. Irinotecan was administered at a dose of 40 mg/m2/day for three consecutive days. Thereafter, it was stopped for four days and was subsequently administered for an additional three days. This course was repeated in 21-28 days cycles. We were able to observe an improvement of images using technetium-99m-bone scans. We did not observe any signs of new tumor lesions for up to five months. The pain was relieved and no serious adverse effects were observed. While the efficacy of irinotecan remains to be confirmed, in many cases, irinotecan can be effective for relapsed ESFT.

Journal

References(8)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top