生体材料としてのタンタルムおよびジルコニウムに関する実験的研究

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  • An experimental study of tantalum and zirconium as biomaterials.

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Although ceramics are popular as biomaterials, metals still have some superior mechanical properties compared with other materials. In the present study, the effects of tantalum and zirconium on cells and tissues were evaluated in vivo and in vitro.<BR>1. Quantification of eluted ions.<BR>1) Ta 99.9%, Zr 97.82%, and Ti 99.9% were examined, and a glass plate was used as a control. The test metals were immersed in a MEM solution at 37°C, and concentration of eluted ions was measured by atomic absorption spectroscopy in 6 months specimens.<BR>In another experiment, the solutions under the same condition were vibrated at 80 count per minute, and concentration of eluted ions was measured in the same way in 1 month specimens.<BR>2) Each test metal was implanted in rabbit mandibles and the implanted metal was removed with the bone tissue at the 16 th week. Linear analysis of eluted ions was then performed by X-ray microanalyzer.<BR>2. Toxicity test of the test metals.<BR>1) Cellular toxicity test by counting the number of colonies.<BR>2) Morphological observation on the growth of cells of L strain cultured on the test metals.<BR>3) Test on the growth and development of chicken embryonal femur by organ culture.<BR>3. Histopathological studies on the reaction of soft and hard tissues to the test metals.<BR>The eluted ions of tantalum and zirconium were very few. Tantalum and zirconium exerted little inhibitory influence on the growth of cells and tissues, and indicated excellent biocompatibility. These results should suggest more use as biomaterials.

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