A study of uric acid concentration in saliva

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  • KIMURA Masatoshi
    The Nippon Dental University, Graduate School of Life Dentistry at Niigata, Oral & Maxillofacial Surgery and Systemic Medicine, Clinical Examination
  • YAMAGUCHI Akira
    The Nippon Dental University, Graduate School of Life Dentistry at Niigata, Oral & Maxillofacial Surgery and Systemic Medicine, Clinical Examination
  • SHIBASAKI Koichi
    The Nippon Dental University, Graduate School of Life Dentistry at Niigata, Oral & Maxillofacial Surgery and Systemic Medicine, Clinical Examination

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  • 唾液中の尿酸濃度に関する研究
  • ダエキ チュウ ノ ニョウサン ノウド ニ カンスル ケンキュウ

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Abstract

Hyperuricemia has increased among middle-aged people due to changes in eating habits and lifestyle. In this study, we examined the clinical significance of uric acid in saliva after investigating the correlation of uric acid concentrations in saliva and serum. The role of uric acid in odontolithiasis was also studied by analyzing the dental calculus. The 197 subjects in the study were outpatients at our hospital or healthy volunteers. For treatment of hyperuricemia, 28 patients had taken benzbromarone and 12 had taken allopurinol. Measurement of uric acid was performed enzymatically. Dental calculus was analyzed using HPLC in 26 patients. The uric acid concentration in saliva and serum showed a significant correlation (r = 0.265, p < 0.01) in all 197 subjects and a more significant correlation (r = 0.517, p < 0.001) in 157 subjects after exclusion of those treated with urate-lowering drugs. In 26 of the 28 subjects (92.9%) treated with benzbromarone, the salivary uric acid concentration was higher than the serum concentration. The concentrations of uric acid in saliva and serum did not show a significant diurnal variation. Uric acid was present in the dental calculus in patients who had not undergone prolonged mouth cleaning. In conclusion, salivary uric acid was significantly correlated with serum uric acid concentration, which suggests that saliva plays an important role in uric acid excretion, and benzbromarone may participate in the mechanism of uric acid excretion in salivary glands. In the absence of prolonged mouth cleaning, uric acid was taken into the dental calculus.

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