口腔扁平上皮癌における第２・３・２１番染色体上のヘテロ接合性消失の解析―予後不良因子の可能性―

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タイトル別名
  • Loss of heterozygosity on chromosomes 2, 3 and 21 in oral squamous cell carcinoma-Possibly a poor prognostic factor-
  • コウクウ ヘンペイ ジョウヒ ガン ニ オケル ダイ2 3 21バン センショクタイジョウ ノ ヘテロ セツゴウセイ ショウシツ ノ カイセキ ヨゴ フリョウ インシ ノ カノウセイ
  • Possibly a poor prognostic factor
  • 予後不良因子の可能性

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Loss of heterozygosity (LOH) is correlated with inactive tumor suppressor gene. The aim of this study was to examine whether LOH on chromosomes 2q, 3p and 21q is correlated with a poor prognostic factor in oral squamous cell carcinoma (OSCC). We analyzed chromosomes 2q, 3p and 21q for LOH in 100 primary OSCCs using 9 markers and constructed a deletion map for these chromosome arms. Significant LOH (>20%) occurred at alleles in chromosome bands D2S1327 (30.1%) at 2q32-35, D3S1007 (23.4%) at 3p25, and D21S369 (31.0%) at 21q11.1. Significant statistical correlation between the incidence of LOH and clinical status was noted. Poor prognoses (deaths) were observed in 12 ofthe 100 patients investigated in the present study and LOH was observed with a high frequency in 9 of the 12 dead patients (75.0%). The number at more than two LOH loci was significant with a poor prognosis (p=0.0390). These findings demonstrate that oral SCC exhibits genetic alterations at multiple loci and that allelic loss at more than three locations is indicative of a poor prognosis. This study demonstrated the prognostic significance of LOH at 2q, 3p and 21q for oral cancer and may help to identify patients who should receive more aggressive treatment.

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