A case of a syndrome of inappropriate antidiuretic hormone secretion and central pontine myelinolysis after chemotherapy for oral cancer

WADA Noriko, MANO Takamitsu, FUKUDA Teruyo, HARADA Koji, UCHIDA Kenichiro, UEYAMA Yoshiya

doi:10.11277/stomatology.61.237

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Other Title

口腔癌化学療法後に抗利尿ホルモン不適合分泌症候群と橋中心髄鞘融解を併発した1例
コウコウガンカガクリョウホウゴニコウリニョウホルモンフテキゴウブンピショウコウグントハシチュウシンズイサヤユウカイオヘイハツシタ 1レイ

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We report a case with marked serum electrolytic disorders, a syndrome of inappropriate antidiuretic hormone secretion (SIADH) and central pontine myelinolysis (CPM) following systemic chemotherapy using cisplatin (CDDP).<br>The patient was a 66-year-old man with squamous cell carcinoma of the tongue and floor of the mouth at the clinical stage rT4N0M0. He was receiving combination chemotherapy with CDDP, docetaxel and 5-FU. Marked hyponatremia appeared within 2 days of the chemotherapy. Furthermore, increases in the antidiuretic hormone level, plasma osmolality, urinary osmolality and urine Na concentration were identified. Finally, SIADH was diagnosed. Water intake was limited and supplementary Na was provided, improving hyponatremia. CPM appeared following correction of the serum Na concentration, but resolved spontaneously over time.<br>We consider that serum sodium should be measured frequently after chemotherapy including CDDP and that an early response is important when hyponatremia occurs.

Journal

Journal of The Japanese Stomatological Society

Journal of The Japanese Stomatological Society 61 (2), 237-242, 2012

Japanese Stomatological Society

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