An Immunological Investigation on Primary Infection with Herpes Simplex Virus Type I.

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  • 単純ヘルペスウイルス１型（ＨＳＶ‐１）初感染における免疫学的検討

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Abstract: Immunological markers were investigated on lymphocytes and neutrophils from 24 patients with primary infection of herpes simplex virus type 1 (HSV-1), and the following results were obtained.<BR>1. Serum levels of IFN-γand sICAM-1 in patients were significantly higher than those in healthy controls.<BR>2. Significant increase of HLA-DR+T (CD3) cell population in patients was observed when compared with healthy controls. Proportions of Leu8+cells and CD57+cells in the patients tended to increase.<BR>3. DNA synthesis in T cells and LAK activity were suppressed during the diseased period, while the NK activity was enhanced.<BR>4. Phagocytosis of neutrophils in patients was not affected, whereas superoxide generation of neutrophils was suppressed.<BR>These results concerning dynamic changes of lymphocyte subsets, nonspecific killings, and active oxygen synthesis of neutrophils seem to indicate characteristic immunopathophysiological alterations in primary HSV-1 infection.

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