書誌事項
- タイトル別名
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- A study on the mechanism of proliferation and progression in malignant salivary gland tumors-Effects of cimetidine-
- ダエキセン アクセイ シュヨウ ノ ゾウショク シンテン メカニズム ニ カンスル ケンキュウ cimetidine ノ オヨボス エイキョウ ニ ツイテ
- Effects of cimetidine
- cimetidineの及ぼす影響について
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抄録
It has been known that neural cell adhesion molecules (NCAM) may be associated with perineural invasion by malignant glandular tumors. In addition, it has been shown that cimetidine, the most studied histamine type-2 receptor (H2R) antagonist, possesses anti-tumor activity against colon, gastric and kidney cancers, and melanomas. This study focused on the perineural invasion of malignant salivary gland tumor, and examined the effects of cimetidine on salivary gland tumor cells, HSG, including the cell viability, the expression of NCAM and H2R, and adhesion to neural cells. MTT assay and confocal laser microscopy revealed that HSG cells underwent apoptosis by cimetidine. Activation of caspases was observed in HSG cells after treatment with cimetidine. Levels of NCAM expression were found to decrease upon treatment with cimetidine in a dose-dependent manner. Furthermore, the adhesion of HSG to neural cells was inhibited by cimetidine. It was suggested that the expression of H2R in HSG cells was involved in the cimetidinemediated down-regulation of NCAM expression and the induction of apoptosis, however, the fact that apoptosis was not induced in HSG cells by other H2R antagonists suggests that cimetidine acts as an anti-tumor drug to HSG cells via the H2R or other pathway. These findings suggested that cimetidine could prevent cell-cell adhesion by down-regulating the expression of NCAM and inhibit the growth, development and perineural invasion of salivary gland tumor cells, followed by induction of apoptosis.
収録刊行物
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- 日本口腔科学会雑誌
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日本口腔科学会雑誌 56 (3), 263-274, 2007
特定非営利活動法人 日本口腔科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681413583744
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- NII論文ID
- 10019565627
- 130004335968
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- NII書誌ID
- AN00189050
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- ISSN
- 21850461
- 00290297
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- NDL書誌ID
- 8910051
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可