疣贅型黄色腫29例の臨床的検討

  • 須賀 則幸
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野II
  • 井出 文雄
    鶴見大学歯学部病理学講座
  • 奥 結香
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野II
  • 田中 章夫
    明海大学歯学部病態診断治療学講座病理学分野
  • 重松 久夫
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野II
  • 鈴木 正二
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野II
  • 草間 薫
    明海大学歯学部病態診断治療学講座病理学分野
  • 坂下 英明
    明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野II

書誌事項

タイトル別名
  • Clinical study of 29 cases of verruciform xanthoma
  • ユウゼイガタ オウショクシュ 29レイ ノ リンショウテキ ケントウ

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抄録

Verruciform xanthoma (VX) is a relatively uncommon lesion of unknown etiopathogenesis that commonly affects the oral mucosa. In this study, we examined the clinical features of VX based on our own 29 cases to clarify the pathogenesis. The female to male ratio was 1:1.2 and there was no sex predilection. The age of the patients ranged from 33 to 84 years, with the mean of 59 years. The lower molar gingiva was the most frequent site (>60%). The majority of lesions were less than 10mm in diameter. The surface appeared to be white and granular. Only one multifocal gingival case was found. General diseases observed in the VX patients were hypercholesterolemia, hepatitis C virus infection and diabetes mellitus. Concomitant local mucosal conditions were lichen planus, leukoplakia and amyloidosis, respectively. Interestingly, 5 patients were wearing illfitting dentures and another 5 cases had a history of tooth extraction at the affected site. Recurrence was observed in one patient who underwent tumor excision. Until 2005, we retrieved 173 non-Japanese and 99 Japanese cases by a comprehensive review of the worldwide literature. Based on the clinicopathological analysis, a potential involvement of irritation and pre-existing inflammation has been suggested in the pathogenesis of the fairly common gingival VX.

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