書誌事項
- タイトル別名
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- Inhibition of vascular endothelial growth factor (VEGF) in oral cancer cells by HIF-1 decoy
- Hypoxia inducible factor 1 HIF 1 デコイ ニ ヨル バイヨウ コウクウガン サイボウ ノ ケッカン ナイヒ ゾウショク インシ サンセイ ヨクセイ
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説明
Angiogenesis plays a critical role in the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic fac torsproduced by tumor cells, and its synthesis has been shown to be modulated through the activation of some transcription factors including HIF-1 induced by hypoxic condition. We transfected synthetic oligodeoxynucleo tides (ODNs) with consensus sequence for HIF-1 bind ing (HIF-1 decoy ODNs) into cultured cancer cells (SAS cells) using the hemagglutinating virus of Japan (HVJ)-liposome method. The hypoxia induced overexpression of VEGF in SAS cells could be apparently suppressed by the transfection of HIF-1 decoy ODNs. These results suggest that the HIF-1 decoy strategy would be effective for regulating tumor growth by reducing angiogenic ac tivityof cancer cells through HIF-1-mediated gene trans activations.
収録刊行物
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- 日本口腔科学会雑誌
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日本口腔科学会雑誌 54 (1), 22-28, 2005
特定非営利活動法人 日本口腔科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681413982848
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- NII論文ID
- 10014375629
- 130004335907
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- NII書誌ID
- AN00189050
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- ISSN
- 21850461
- 00290297
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- NDL書誌ID
- 7319180
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可