A case of intraosseous solitary neurofibroma of the mandible

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  • TOCHIHARA Shiomi
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • SATO Chika
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • SATO Toru
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • ASADA Koichi
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine
  • ISHIBASHI Katsunori
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine

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  • 顎骨内に発生した孤立性神経線維腫の１例
  • ガクコツ ナイ ニ ハッセイ シタ コリツセイ シンケイ センイ シュ ノ 1レイ

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Abstract

Tumors originating from peripheral nerves are relatively rare in the oral cavity. Such lesions occasionally appear as a central lesion of the mandible, and many of these are Schwannomas. However, central neurofibroma is quite rare. We present a case of intraosseous neurofibroma of the mandible in a 35-year-old Japanese woman. The lesion showed as a quail egg-sized radiolucency in the canine-first premolar region of the left mandibular body, overlapping the mental foramen. The lesion was enucleated with involvement of the inferior alveolar nerve. Histopathologically, the unencapsulated lesion comprised a proliferation of densely packed spindle cells and some collagenous tissue with irregular arrangement. Nerve fibers were scattered throughout the lesion. Immunohistochemistry showed S-100 protein in scattered nerve fibers within the tumor, while proliferating spindle cells were negative for this protein.

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