Determination of Thyroid Autoantibodies and Functional Tests of Thyroid Disorders

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  • SAKURAMI Takehiko
    The 2nd Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • KURIHARA Jiro
    The 2nd Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • KAJI Takahiko
    The 2nd Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • 上原 広道
    京大第二内科
  • NANBA Hidehiro
    The 2nd Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • FUKASE Masaichi
    The 2nd Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • KATSURA Yoshimoto
    Institute of Chest Diseases at Kyoto University

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Other Title
  • サイロイドテストおよびマイクロゾームテストによる甲状腺疾患に対する甲状腺抗体の測定と機能検査に関する検討
  • サイロイドテスト オヨビ マイクロゾームテスト ニ ヨル コウジョウセン シッカン ニ タイスル コウジョウセン コウタイ ノ ソクテイ ト キノウ ケンサ ニ カンスル ケントウ

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Immunological and endocrinological studies were carried out on patients with thyroid disorders.<BR>Circulating antibodies to thyroglobulin were demonstrated by tanned red cell hemagglutination. Serum antibodies to microsome of thyroid epithelial cells were also demonstrated by tanned red cell hemagglutination.<BR>These thyroglobulin and microsome-coated tanned red blood cells are the usual instrument for the hemagglutination test, which can be efficiently performed with a commercially prepared reagent (Fuji-Zoki Inc.).<BR>The frequency of detection of hemagglutinating antibodies to microsome in patients with hyperthyroidism was greater in patients with chronic thyroiditis.<BR>Many patients with hyperthyroidism have high titers of hemagglutinating antibodies, and such high titers are unusual in any other thyroid disease.<BR>The frequency of detection of thyroid autoantibodies can not be correlated to the function tests and this relationship does not cover the titer of thyroglobulin or microsomal antibodies.

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