Effect of Synthetic Thyrotropin-Releasing Factor (TRF) on Pituitary TSH Secretion in Man

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  • SAKODA Masahiro
    Second Department of Internal Medicine, Kobe University School of Mdicine Koke, Japan
  • OTSUKI Makoto
    Second Department of Internal Medicine, Kobe University School of Mdicine Koke, Japan
  • OKUBO Masao
    Second Department of Internal Medicine, Kobe University School of Mdicine Koke, Japan
  • BABA Shigeaki
    Second Department of Internal Medicine, Kobe University School of Mdicine Koke, Japan

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Other Title
  • TRF testに関する臨床的研究
  • Glucocorticoid投与症例並びにCushing症候群におけるTRF test
  • Glucocorticoid トウヨ ショウレイ ナラビニ Cushing ショウコウグン ニ オケル TRF test
  • Part 4. TRF Test in Cases with Cushing's Syndrome and Long-Term Corticosteroid Administration
  • 第4編 : Glucocorticoid投与症例並びにCushing症候群におけるTRF test

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Although many factors are thought to be responsible for regulating pituitary TSH secretion, TSH release is generally under the control of TRF and serum thyroxine concentration.<BR>However, TSH release is influenced by other hormone concentrations in the serum such as estradiol and especially glucocorticoid. Influence of glucocorticoid administration or increased serum corticoid concentration on TRF that induced TSH release was observed in cases with long-term corticosteroid administration or Cushing's syndrome.<BR>TRF that induced TSH release was inhibited in cases with long-term glucocorticoid administration such as chronic nephritis, bronchial asthma, bronchogenic carcinoma and sarcoidosis. These cases had been administrated 8,000 mg or more of glucocorticoid in cortisol equivalent.<BR>Distinct plasma TSH increase by TRF were observed in cases with short-term or intermittent glucocorticoid administration.<BR>No or a slight rise in plasma TSH levels occurred following TRF in patients with Cushing's syndrome who had adrenocortical adenoma.<BR>Normal TSH increase following increased doses of TRF was obtained from cases with the above-mentioned long-term corticoid administration.<BR>Glucocorticoid treatment in large doses and increased serum corticoid concentration seemed to inhibit plasma TSH increase following certain doses of TRF.

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