Two cases of hepatitis B virus associated glomerulonephritis - Successful induction of seroconversion and diminished proteinuria.
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- IKEDA Shuji
- The Third Department of Internal Medicine and Okayama University Medical School
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- YOSHINAGA Yasuhiko
- The Third Department of Internal Medicine and Okayama University Medical School
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- TANIAI Kazuhi
- The Third Department of Internal Medicine and Okayama University Medical School
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- TAKAHASHI Kayo
- The Third Department of Internal Medicine and Okayama University Medical School
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- MAKINO Hirofumi
- The Third Department of Internal Medicine and Okayama University Medical School
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- OTA Zensuke
- The Third Department of Internal Medicine and Okayama University Medical School
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- MANABE Kohji
- The First Department of Internal Medicine Okayama University Medical School
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- YAMADA Gotaro
- The First Department of Internal Medicine Okayama University Medical School
Bibliographic Information
- Other Title
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- Ｓｅｒｏｃｏｎｖｅｒｓｉｏｎの誘発により良好な経過をとったＢ型肝炎ウイルス（ＨＢＶ）腎症の２例
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Abstract
B型肝炎ウイルス(HBV)関連膜性糸球体腎炎とHBV関連膜性増殖性糸球体腎炎の2例を経験し,おのおのの腎糸球体に, HBe抗原の存在を証明した.これまで, HBV腎症においてはseroconversionと相前後して腎症状の改善が見られることは知られているが,積極的にseroconversionを誘導して治療を行った報告は少ない.そこで,今回の2症例に対して, HBe抗原抗体系のseroconversionを自的に,副腎皮質ステロイド中断療法,インターフェロン療法を行ったところ,血中HBe抗原の消失, HBe抗体の出現と共に,尿蛋白の減少,消失が認められ,良好な経過をとった.以上の経験により, HBV腎症に対して積極的なseroconversionの誘導が有効と考え報告した.
Journal
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- Nihon Naika Gakkai Zasshi
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Nihon Naika Gakkai Zasshi 78 (12), 1752-1757, 1989
The Japanese Society of Internal Medicine