CLINICAL STUDIES ON THE DEPRESOR EFFECT OF SHIBU AGAINST HYPERTENSION

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  • 柿澁の血圧下降作用に關する臨床的研究
  • カキシブ ノ ケツアツ カコウ サヨウ ニ カンスル リンショウテキ ケンキュウ

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Abstract

Since many years ago “Shibu”, unripe persimmon's acrid juice old enough to be drink able, has privately been used as a remedy of hypertension and apoplexy among the people in Northern Japan, but it seems to me that there are neither exact clinical, nor precise experimental investigations. Suggested by it, I studied accurately on the clinical effect of “Shibu” for many patients suffering from essential hypertension.<br>1) “Shibu” shows an unquestionable depressor effect on the high blood pressure of hypertensive patient. It lowered not only the systolic blood pressure, but also the diastolic blood pressure.<br>2) Its side action is some stomach symptoms and obstipation probably caused by “Shibuol”, a tannin-like substance contained in the acrid juice. Therefore “Shibuol” was precipitated in the 0.5% gelatine solution, and the filtrate also showed the likewise depressor effect without any unpleasant side action.<br>3) “Shibu” has no harmful influence upon the blood corpuscles, the function of heart, kidney and liver.<br>4) It must be most useful as an adjunct reinforcing the curing action of other drugs against hypertension.

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