1. Ectopic Fat Disposition and Lipotoxicity.
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- Shimabukuro Michio
- Department of Cardio-Diabetes Medicine, The University of Tokushima Graduate School of Health Biosciences Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University of the Ryukyus Graduate School of Medicine
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- Yamakawa Ken
- Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University of the Ryukyus Graduate School of Medicine
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- Masuzaki Hiroaki
- Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University of the Ryukyus Graduate School of Medicine
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- Sata Masataka
- Department of Cardiovasucular Medicine, The University of Tokushima Graduate School of Health Biosciences
Bibliographic Information
- Other Title
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- 1.肥満症と異所性脂肪,脂肪毒性
- 肥満症と異所性脂肪,脂肪毒性
- ヒマンショウ ト イショセイ シボウ シボウ ドクセイ
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Description
遊離脂肪酸はエネルギー基質であると同時にさまざまなシグナル分子の基質でもあり,インスリン作用,インスリン合成・分泌に影響を与える.肥満症にともなう過剰な遊離脂肪酸は,耐糖能を悪化させる.遊離脂肪酸によるインスリン作用の障害を(広義の)脂肪毒性,インスリン分泌能に及ぼす悪影響を膵β細胞脂肪毒性(狭義の脂肪毒性)と呼ぶ.最近,脂肪組織以外の臓器に蓄積する脂肪(異所性脂肪)の動態に注目が集まっており,各臓器で何らかの病的意義を有する可能性がある.<br>
Journal
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- Nihon Naika Gakkai Zasshi
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Nihon Naika Gakkai Zasshi 100 (4), 983-988, 2011
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390282681420646784
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- NII Article ID
- 10029096787
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- NII Book ID
- AN00195836
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- COI
- 1:CAS:528:DC%2BC3MXmsFaksL4%3D
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- ISSN
- 18832083
- 00215384
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- NDL BIB ID
- 11094224
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- PubMed
- 21626835
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed