-
- 鶴間 美代治
- 新潟大學医學部桂内科教室
書誌事項
- タイトル別名
-
- EXPERIMENTAL AND CLINICAL STUDIES ON UNSATURATED SEVEN-MEMBERED RING COMPOUNDS
- フホウワ 7インカン カゴウブツ ノ ジッケンテキ ナラビニ リンショウテキ ケンキュウ 23
- 23TH REPORT: ANTIVIRAL ACTION OF TROPOLONE AND ITS COMPOUNDS AGAINST JAPANESE B ENCEPHALITIS VIRUS IN VITRO
- 第23報 Tropolone及びその誘導体の日本腦炎ビールスに對する試驗管内作用
この論文をさがす
説明
In-vitro experiment was conducted on the action of tropolone (Trp) and its eight derivatives against Japanese B encephalitis virus (Nakayama strain).<br>The substance to be examined, dissolved in tween 80, was added to the supernatant fluid obtained by ultracentrifuging the brain emulsion of virus-inoculated mice. After incubating at 22°C for 1 hour, the mixture was intracerebrally inoculated into a fixed number of mice. Comparing the result with the control, logarithm difference (log diff.) of LD50 was computed. Antiviral potency is represented by -log diff.<br>The result was as follows. At 1000 γ/cc the following values were registered:<br>Hinokitiol (Hi) (-log diff.=4.2), Hi-natrium (2.5), Trp (4.1), <br>3-monobromotrp (3.2), 3-5-dibromotrp (3.3), 3-7-dibromotrp (5.3), <br>3-5-7-tribromotrp (4.9), mercaptotropone (2.0)<br>3-5-7-tribromo-2-aminotropone showed no potency against virus dilutions stronger than 10-6.<br>Hi, Trp, 3-7-dibromotrp and 3-5-7-tribromotrp showed considerable potency at 100 γ/cc. Even at 10γ/cc Hi and Trp registered a slight potency.<br>On the other hand, it was noted that the antiviral potency of 3-monobromotrp and 3-5-dibromotrp at 100 γ/cc was very weak, and that Hi-Natrium and mercaptotropone revealed no potency at 100 γ/cc.
収録刊行物
-
- 日本内科学会雑誌
-
日本内科学会雑誌 45 (12), 1327-1333, 1957
一般社団法人 日本内科学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681420957440
-
- NII論文ID
- 130000881999
-
- NII書誌ID
- AN00195836
-
- ISSN
- 18832083
- 00215384
-
- NDL書誌ID
- 10059900
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可