ジメトンおよびメチルジメトンによるゴキブリの神経機能変化とコリンエステラーゼ阻害

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タイトル別名
  • Nervous and Cholinesterase Activities in the Cockroach as Affected by Demeton and Methyldemeton
  • サッチュウザイ ノ サヨウ キコウ ニ カンスル ケンキュウ 18
  • Studies on the Mechanism of Action of Insecticides (XVIII)
  • 殺虫剤の作用機構に関する研究 (XVIII)

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1. The effects of thiono- and thiolisomers of both demeton and methyldemeton on the activity of the nerve cord of the American cockroach and on the cholinesterase activity have been studied.<br>2. Both isomers of methyldemeton caused an increase in spontaneous activity and a prolongation of synaptic after-discharge, which were followed by a burst of discharges and a final synaptic block. These effects were reversible on washing with normal Ringer's solution when a weak concentration was used.<br>3. Both isomers of demeton exerted almost the same effect as that of methyldemeton, but differed in that the prolongation of synaptic after-discharge was preceded by a brief period of depression of postsynaptic response.<br>4. Four isomers all inhibited cholinesterase of the nerve cord in vitro, concentration for 50 per cent inhibition being of the order of 10-6M.<br>5. The cholinesterase activity of nerve was half inactivated at the moment when spontaneous activity was increased and synaptic after-discharge was prolonged after treatment with demeton or methyldemeton.<br>6. It is concluded that the inhibition of cholinesterase is mainly responsible for the changes in nervous activity. Additional mechanisms are suggested for the action of demeton.

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