Interrelation between Bait Consumption, Prolongation of Prothrombin Time, Mortality and Decrease of Blood Capillary Resistance in Coumarin Rodenticide Warfarin

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  • KUSANO Tyuzi
    Laboratory of Applied Zoology, Faculty of Agriculture, Tokyo University of Education Laboratory of Applied Entomology, Faculty of Agriculture, Tottori University

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  • クマリン系殺そ剤ワルファリンにおける毒飼消費量,Prothrombin Timeの延長,死亡率,血管抵坑減弱の相互関係
  • クマリンケイ サッソザイ ワルファリン ニ オケル ドクシショウヒリョウ , Prothrombin Time ノ エンチョウ , シボウリツ , ケッカン テイコウ ゲン ジャク ノ ソウゴ カンケイ

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1. Interrelation between warfarin concentration, bait consumption per day and mortality: With successive administration of poisoned bait containing more than the minimum effective concentration of warfarin, it was found that the time or amount of bait consumption per day and the numbers of times of administration are more responsible for mortality rather than the concentration of warfarin.<br>2. Interrelation between warfarin concentration, time of bait consumption, prolongation of prothrombin time and mortality: The greater the consumption of warfarin bait per day, the lower was the concentration needed for the distinguished prolongation of the prothrombin time of the poisoned mice and for the high mortality. However, there was no close relation between the days of survival, warfarin concentration and the days necessary for the prothrombin time to attain over 300sec.<br>3. The resistance of blood capillary decreased markedly in parallel with the increase in prothrombin time and in the numbers and times of administration, but no obvious relation was found between the resistance of blood capillary and warfarin concentration.<br>4. Haemorrhage in the mice killed by warfarin could be classified into nine types based on the degree of haemorrhage. Among these, the haemorrhage types of the brain and the digestive organ were predominated.<br>5. From the results of studies up to date, it is concluded that the decrease of blood capillary resistance running parallel with the prolongation of the prothrombin time plays a major role in the toxic effect of warfarin.

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