Heat-killed lactobacillus casei, LC-9018, as an interferon inducer.

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  • SUZUKI Fujio
    Department of Microbiology, Kumamoto University School of Medicine
  • OKABE Hiroaki
    Department of Microbiology, Kumamoto University School of Medicine
  • TODAKA Takeomi
    Department of Microbiology, Kumamoto University School of Medicine
  • HAYASHI Keiko
    Department of Veterinary Radiology, College of Agricultural Veterinary Medicine, Nihon University
  • KOIDE Fusaoki
    Department of Veterinary Radiology, College of Agricultural Veterinary Medicine, Nihon University
  • MAEDA Hiroshi
    Department of Microbiology, Kumamoto University School of Medicine
  • ISHIDA Nakao
    Tohoku University

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Other Title
  • 乳酸かん菌ＬＣ‐９０１８のインターフェロン誘起能
  • ニュウサン カンキン LC-9018 ノ インターフェロン ユウキノウ

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Abstract

A viral inhibitory activity was found in sera of ddY mice treated intraperitoneally with heat-killeld Lactobacillus casei LC-9018, at doses of 0.78-200mg/kg. The activity was ascribed to interferon(s) (IFN). A significant IFN activity of the sera of mice appeared in 18 hours and it reached a peak between 18-24 hours after the stimulation. In vitro treatment with anti-IFNγ antiserum neutrarized 67% of the IFN activity. The IFN-inducing activity of LC-9018 was diminished when mice were pretreated with monoclonal anti-Thy1, 2 antibody or carrageenan. These results suggest that T-cells and macrophages may be required for IFN induction with LC-9018.

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