書誌事項
- タイトル別名
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- In vitro activation of immune cells by a mycolic acid-containing glycolipid, trehalose-2,3,6'-trimycolate, derived from Gordona aurantiaca.
- Gordonaゾク サイキン サイボウヘキ ユライ ノ ミコールサン ガンユウ
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説明
A mycolic acid-containing glycolipid, trehalose-2, 3, 6'-trimycolate (GaGM), derived from Gordona aurantiaca, an acid-fast bacteria closely related taxonomically to Mycobacterium, was investigated for its immune adjuvant activity in vitro. The liposomes containing GaGM showed strong mitogenic effects on murine spleen cells at the doses used (25-100μg/ml), but not on T-cell-depleted spleen cells or macrophage-depleted spleen cells. These results suggest that the mitogenic property of liposomes containing GaGM differs from that of such as lipopolysaccharide, a B-cell mitogen and that its mitogenic effects depend on the presence of macrophages. In addition, liposomes containing GaGM augmented the mixed lymphocyte reaction (MLR) and in vitro induction of cytotoxic T-lymphocytes (CTLs) against allogeneic tumor cells.<br>These results suggest that liposomes containing GaGM have immune adjuvant properties in vitro and the adjuvant activity may be related to such cytokines as interleukin-1 and -2.
収録刊行物
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- 日本細菌学雑誌
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日本細菌学雑誌 44 (6), 797-803, 1989
日本細菌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681426440960
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- NII論文ID
- 130001386360
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- NII書誌ID
- AN00189800
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- ISSN
- 18824110
- 00214930
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- NDL書誌ID
- 3262540
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- PubMed
- 2533624
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可