内毒素に類似する生物学的作用を示すＢＣＧ由来の免疫調節因子の抗腫よう作用

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  • Antitumor effects of a novel immunomodulator, holding many bioactivities in common with endotoxins, derived from Mycobacterium bovis BCG.
  • ナイ ドクソ ニ ルイジスル セイブツガクテキ サヨウ オ シメス BCG ユ

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An immunostimulatory agent partially purified from the aqueous phase of phenol-water extracts of BCG was studied for its anti-tumor effects in mice. The agent exerted marked suppressive effects on sarcoma 180 inoculated into ICR mice and caused extensive hemorrhagic necrosis and regression and high incidence of complete cure of Meth A fibrosarcoma established in BALB/c mice as did a reference Escherichia coli lipopolysaccharide (LPS), although much higher doses of the agent than those of LPS were used. The antitumor effects of the agent were accompanied with considerable loss of body weight of test animals, but the weight loss was less than that caused by the reference LPS and ceased when the drug administration was stopped. A synergistic anti-Meth A tumor effect was noted in combined use of the agent and Nα-(N-acetylmuramyl-L-alanyl-D-isogulutaminyl)-Nε-stearoyl-L-lysine under the experimental conditions where each compound was scarcely active.

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