二,三の組織の凝血促進様物質に対するワルファリンの影響

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  • Effects of Warfarin on a Blood Coagulation Accelerator-Like Substance of Several Tissues in Mice
  • ニ , サン ノ ソシキ ノ ギョウケツ ソクシン ヨウ ブッシツ ニ タイスル ワルファリン ノ エイキョウ

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The nature of a blood coagulation acceleratorlike substance contained in brain, spleen, lever, kidney and lung in mice and the effects of warfarmn on this substance were investigated.<br>The estimation of the accelerating effects of the saline extracts of various tissues and of the saline suspensions of acetone powders of various tissues (tissue powder suspensions) on blood coagulation of normal and warfarin-treated plasma were based upon the observations on the differences between the coagulation time of a mixture, CaCl2 + various tissue extracts or tissue powder suspensions+ test plasma, and the recalcification time or the prothrombin time of test plasma, or between the coagulation time of a mixture, CaCl2+ brain thromboplastin + various tissue extracts or tissue powder suspensions + test plasma, and the prothrombin time of test plasma. Further, the effects of normal stored serum on the accelerating action by various tissue extracts and tissue powder suspensions of blood coagulation were estimated by the differences between the coagulation times of mixtures with and without various tissue extracts or tissue powder suspensions, the mixture being either warfarin plasma + CaCl2, CaCl2 + normal stored serum, or CaCl2 + normal stored serum + brain thromboplastin.<br>The following results were obtained:<br>1. A blood coagulation accelerator-like substance is contained in various tissues, and it acts more strongly on the warfarin plasma than it does on the normal plasma. This substance is completely adsorbed by Ca3(PO4)2 but incompletely by BaSO4, and is somewhat unstable on incubation at 50∼56°C for 15min.<br>The substance in the tissue extracts accelerates the blood coagulation of warfarin plasma in the presence of brain thromboplastin or a mixture of normal stored serum + CaCl2, but does not acclerate or rather inhibits the blood coagulation of warfarin plasma in the presence of a mixture of brain thromboplastin + normal stored serum + CaCl2.<br>The substance in the tissue powder suspensions accelerates the blood coagulation of warfarin plasma in the presence of a mixture of brain thromboplastin + CaCl2, but does not accelerate the blood coagulation of warfarin plasma in the presence of a mixture of normal stored serum + CaCl2.<br>2. A blood coagulation accelerator-like substance in various tissues disappears completely by warfarin poisoning.

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