A Case of Subacute Fulminant Hepatitis Induced by Methyldopa

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  • Koizumi Tadashi
    Department of Gastroenterology and Hepatology of Japan Community Health Care Organization Hokkaido Hospital
  • Furuya Ken
    Department of Gastroenterology and Hepatology of Japan Community Health Care Organization Hokkaido Hospital
  • Baba Masaru
    Department of Gastroenterology and Hepatology of Japan Community Health Care Organization Hokkaido Hospital
  • Sadaoka Kuniaki
    Department of Gastroenterology and Hepatology of Japan Community Health Care Organization Hokkaido Hospital
  • Sekiya Chihiro
    Department of Gastroenterology and Hepatology of Japan Community Health Care Organization Hokkaido Hospital
  • Hattori Atsuo
    Department of Pathology of Japan Community Health Care Organization Hokkaido Hospital
  • Goto Ryoichi
    Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine
  • Aoyagi Takeshi
    Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine
  • Yamashita Kenichirou
    Department of Organ Transplantation, Hokkaido University Graduate School of Medicine
  • Shimamura Tsuyoshi
    Division of Organ Transplantation, Hokkaido University Hospital

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Other Title
  • メチルドパにより亜急性型劇症肝炎を発症した1例
  • 今月の症例 メチルドパにより亜急性型劇症肝炎を発症した1例
  • コンゲツ ノ ショウレイ メチルドパ ニ ヨリ アキュウセイガタゲキショウ カンエン オ ハッショウ シタ 1レイ

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Abstract

メチルドパは妊娠中や授乳中の安全性が確立されている降圧薬であるが，発売後早くから肝機能障害の副作用が報告されている．患者は40歳，女性で妊娠判明後，降圧薬をメチルドパに変更された．分娩3カ月後，重篤な薬物性肝障害にて当院に入院となった．入院後劇症化を認め，血液浄化療法，脳死肝移植にて救命できた．メチルドパ内服中は定期的な肝機能のモニタリング，並びに肝機能障害出現時には速やかな中止が重要と考えられた．

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