A novel immunomodulator derived from Mycobacterium bovis BCG which holds many bioactivities in common with endotoxins.
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- IKEDA-FUJITA Takako
- Osaka Research Institute, Sawai Pharmaceutical Co. Ltd. Department of Oral Microbiology, Osaka University Dental School
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- KOTANI Shozo
- Department of Oral Microbiology, Osaka University Dental School
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- TSUJIMOTO Masachika
- Department of Oral Microbiology, Osaka University Dental School
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- OGAWA Tomohiko
- Department of Oral Microbiology, Osaka University Dental School
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- TAKADA Haruhiko
- Department of Oral Microbiology, Osaka University Dental School
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- TAKAHASHI Ichiro
- Department of Oral Microbiology, Osaka University Dental School
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- SHIMAUCHI Hidetoshi
- Department of Oral Microbiology, Osaka University Dental School
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- KOKEGUCHI Susumu
- Department of Oral Microbiology, Okayama University Dental School
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- KATO Keijiro
- Department of Oral Microbiology, Okayama University Dental School
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- OKAMURA Haruki
- Department of Biology, Hyogo College of Medicine
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- TAMURA Toshihide
- Department of Biology, Hyogo College of Medicine
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- YANO Ikuya
- Department of Bacteriology, Osaka City University Medical School
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- TANAKA Shigenori
- Tokyo Research Institute, Seikagaku Kogyo Co. Ltd.
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- KATO Yoshiko
- Osaka Research Institute, Sawai Pharmaceutical Co. Ltd.
Bibliographic Information
- Other Title
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- 内毒素に類似する生物学的作用を示すBCG由来の免疫調節因子
- ナイ ドクソ ニ ルイジスル セイブツガクテキ サヨウ オ シメス BCG ユ
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Abstract
An immunostimulator agent was partially purified from the phenol-water extracts of M. bovis BCG by fractionation with Sepharose 6B and 4B columns. The agents showed multifold bioactivities, many of which are common to endotoxins. They are pyrogenicity, lethality in galactosamine-loaded mice, induction of tumor-necrosis-factor and interferons α/β in primed mice and immunoadjuvancy enhancing antibody production following in vivo administration, activation of the clotting enzyme cascade of the horseshoe crab, complement activation, and stimulatory effects on murine splenocytes and guinea-pig macrophages in in vitro assay. Although the chemical entity responsible for the above bioactivities has not yet been fully understood, chemical analysis revealed that the bioactive agent is polysaccharide (ca 92%), whose main component sugars are mannose and arabinose, connected with fatty acids (ca 10%), amino acids and amino sugars (ca 3.5% together), containing no detectable amounts of such constitutes characteristic of known immunomodulators of bacterial origin as LPS, cord factors, cell wall peptidoglycans, lipoteichoic acids and biologically active nucleic acids.
Journal
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- Nippon Saikingaku Zasshi
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Nippon Saikingaku Zasshi 42 (3), 597-602, 1987
JAPANESE SOCIETY FOR BACTERIOLOGY
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Keywords
Details 詳細情報について
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- CRID
- 1390282681427377280
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- NII Article ID
- 130001385936
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- NII Book ID
- AN00189800
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- ISSN
- 18824110
- 00214930
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- NDL BIB ID
- 3136027
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- PubMed
- 3312707
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed