Metabolism and Toxicity of Salithion, 2-Methoxy-4H-1, 3, 2-Benzodioxaphosphorin-2-Sulfide

DOI JASI Web Site
  • OHKAWA Hideo
    Department of Agricultural Chemistry, Kyushu University Division of Entomology, University of California
  • ETO Morifusa
    Department of Agricultural Chemistry, Kyushu University
  • OSHIMA Yasuyoshi
    Department of Agricultural Chemistry, Kyushu University

Bibliographic Information

Other Title
  • 殺虫剤サリチオン(2-methoxy-4H-1, 3, 2-benzodioxaphosphorin-2-sulfide)の代謝と毒性
  • サッチュウザイ サリチオン 2-methoxy-4H-1 , 3 , 2-benzodioxaphosphorin-2-sulfide ノ タイシャ ト ドクセイ

Search this article

Description

Salithion, an insecticide analogous to TOCP-metabolite, did not cause ataxia in chickens injected with a total of 80mg/kg in daily doses. Salithion-32P was synthesized and administered orally to mice and topically to houseflies. Autoradiography of body slices and radioassay of whole body and excreta indicated that Salithion was rapidly decomposed in mice and excreted. Chloroform-soluble 32P in the body was only 2.4% of the administered 32P at three hours after treatment. On the other hand, Salithion persisted in the houseflies for a relatively long time. More than 4% of the applied or 10% of the absorved Salithion was found in the chloroform-soluble fraction of houseflies at 24 hours after treatment. Besides Salithion, only its oxo analog was detected in the chloroform-soluble fraction by the autoradiogram of thin layer chromatography.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top