BCG接種マウスのインフルエンザ・ウイルス静注毒性に対する抵抗性の変化について (第1報)

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  • Resistance-promoting effect on influenza A virus after injection with BCG in mice First Report
  • BCG セッシュ マウス ノ インフルエンザ ウイルス ジョウチュウ ドクセイ ニ タイスル テイコウセイ ノ ヘンカ ニ ツイテ 1

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At the 9th day after BCG-injection, SMA strain mice showed the marked reduction of LD50 for endotoxin from E. coli 0-111 as compared with control mice.<br>On the contrary, the BCG-injected mice showed two to three fold increase of LD50 for the PR 8 strain of influenza A virus.<br>This resistance promoting effect was shared with not only living BCG cells but also heat-killed BCG cells, but not with BCG-filtrate.<br>The effect was most effectively exhibited when BCG was inoculated intravenously, intermediately when intraperitoneally and least when subcutaneously. The inocuation by subcutaneous route was almost ineffective.<br>The effect was exhibited from about the 6th day after BCG-inoculation, reached the peak at the 10th to 12th day, and continued even after 30 days.<br>The effect of BCG inoculation on the intranasal infection of PR 8 was not exhibited.<br>There were no significant differences of LD50, the degree of consolidation and the H. A titre of the lungs of dead mice, between BCG-inoculated and control mice.

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