5-n-Butyl-1-Cyclohexyl-2, 4, 6-Trioxoperhydropyrimidine (BCP)の細菌感染に及ぼす影響

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  • 近藤 正煕
    武田薬品工業株式会社研究開発本部生物研究所第2部
  • 山崎 俊幸
    武田薬品工業株式会社研究開発本部生物研究所第2部
  • 土屋 皖司
    武田薬品工業株式会社研究開発本部生物研究所第2部

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タイトル別名
  • The Influence of 5-n-Buthyl-1-Cyclohexyl-2, 4, 6-Trioxo-Perhydropyrimidine (BCP) to Bacterial Infection
  • 5-n-Butyl-1-Cyclohexyl-2 , 4 , 6-Trioxoperhydropyrimidine BCP ノ サイキン カンセン ニ オヨボス エイキョウ

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説明

The influence of 5-n-butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) upon experimental bacterial infection in mice was observed in comparison with that of cortisone.<br>Suspensions of Staph. aureus and K. peneumoniae in varying dilution of an overnight brain heart infusion broth culture were injected intravenously into mice. The drug was administered (SC) simultaneously with the infection as a single dose and four successive doses once daily for 4 days. The survival time of the treated animals and the number of living staphylococci in mice kidney were observed.<br>While cortisone depressed markedly the resistance of animals against the injection as reported previously by other authors, BCP gave no appreciable influences upon the course of infection in mice. This conclusion was based upon the two criteria described; survival time and the viable units of Staph. aurens in mice kidney.

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