ツベルクリン活性ペプチド (TAP) の生物学的性状に関する研究

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タイトル別名
  • Studies on Biological Properties of Tuberculin Active Peptide
  • ツベルクリン カッセイ ペプチド TAP ノ セイブツガクテキ セイジョウ ニ カンスル ケンキュウ 1
  • Ist Report. On Antigenicity of Tuberculin Active Peptide
  • 第1 報ツベルクリン活性ペプチドの抗原性について

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There have been many reports on the antigenicity to induce hypersensitivity of the tuberculoprotein in experimental animal. It is still a matter of controversy, however, whether the hypersensitivity induced by the administration of tuberculoprotein is of the delayed tuberculin type or of the anaphylactic type.<BR>In the present studies, it was attempted principally to test the antigenicity of various kinds of tuberculoproteins and tuberculin active peptide in the induction of delayed type hypersensitivity in guinea pigs. The following results were obtained.<BR>It was observed that the guinea pigs sensitized with purified tuberculin proteins (PPD-S and π) did not show any sign of hypersensitivity at 4 hours after skin testing but developed a marked positive response to 1.0 γ PPD-S at 24 and 48 hours. Therefore, all of these reactions are considered to be of the delayed type in their time of onset<BR>Morever, relatively large amounts of extremely pure tuberculin active peptide in water-in-oil emulsion was not able to induce either immediate or delayed type hypersensitivity during the whole period of 10 weeks after the inoculation of tuberculin active peptide.<BR>Accordingly, it is suggested that the ability of various kinds of purified tuberculoprotein derivatives to induce tuberculin type hypersensitivity reported by many researchers was either due to the contamination of lipopolysaccharide and other bacillary constituents or the antigenicity of protein itself, while tuberculin active peptide had no or very low, if any, antigenicity to induce delayed type hypersensitivity.

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