新生ニワトリヒナの飼料摂取量に及ぼすモルヒネと キョートルフィンの中枢投与の影響

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  • Influence of Intracerebroventricular Administration of Morphine and Kyotorphin on Food Intake of the Neonatal Chick.

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The present study was done to determine whether i.c.v, injection of morphine, or kyotorphin (KTP), an endogenous [Met5]-enkephalin-releasing dipeptide in mammals, increases feeding behavior in the neonatal chick. Food intake was significantly suppressed by intracerebroventricular (i.c.v.) administration of morphine with a narcoleptic response. However, i.c.v. administration of KTP at the levels of 2.5-50μg failed to alter food intake of chicks compared with the saline control over 2hr. It is suggested that KTP may not affect endogenous opioids release in the brain of neonatal chicks.

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