The Effect of Antithrombotic Treatment of Dalteparin after Mitral Valve Repair under Cardiopulmonary Bypass in Dogs
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- FUJIWARA Megumi
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- MIZUNO Takeshi
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- MIZUKOSHI Takahiro
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- SHINODA Asako
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- UCHIDA Shuhei
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- SAWADA Tamotsu
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- TAKEUCHI Junichiro
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- MIZUNO Masashi
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- HARADA Kayoko
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- KASUYA Arane
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- FUNAYAMA Marina
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
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- UECHI Masami
- Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of ioresouce Sciences, Nihon University
Bibliographic Information
- Other Title
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- イヌの体外循環下僧帽弁修復術後における抗血栓療法の効果
- イヌ ノ タイガイ ジュンカン カソウボウベン シュウフク ジュツゴ ニ オケル コウケッセン リョウホウ ノ コウカ
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Abstract
We evaluated the effect of ozagrel and darteparin after mitral valve repair under cardiopulmonary bypass in dogs. A total of 32 dogs were included in this study (9.7±2.3 years old, 5.3±3.7 kg). The two out of 32 cases were excluded because of death with aspiration or hypotension within 24 hours after surgery. Dogs (n=14) were treated with hydrochloric acid ozagrel orally (p.o.) for a dose of 5 or 10 mg/kg BID, or Low molecular weight heparin; dalteparin (5 IU/kg/hr) after the operation. The dose of dalteparin was increased gradually (until 50 or 75 IU/kg/hr), and then changed to subcutaneous injection of 50–100 IU/kg/day for 6–12 days (n=16). After that, ozagrel hydrochloride (10 mg/kg p.o., BID), a thoromboxane A 2 synthase inhibitor, was administered for 1 month instead of dalteparin. In this study, it was suggested there were less thrombosis in the darteparin-treated group. The number of platelets increased earlier in darteparin-treated group. Also, there was significant lower rate of hyperlipasemia in the darteparin-treated group. This study has shown the effect of darteparin in preventing adverse events, and it was emphasized the importance of anticoagulation management after mitral valve repair.
Journal
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- Advances in Animal Cardiology
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Advances in Animal Cardiology 46 (1), 1-7, 2013
Japanese Society of Veterinary Cardiology
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Details 詳細情報について
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- CRID
- 1390282681434019712
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- NII Article ID
- 130004785266
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- NII Book ID
- AN10192925
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- ISSN
- 18835260
- 09106537
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- NDL BIB ID
- 025561622
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed