グルカゴン様ペプチド-1(GLP-1)による新生ニワトリヒナの摂食抑制効果に対するナロキソンの効果

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  • Effect of Naloxone on the Anorexic Action by Glucagon-Like Peptide-1(7-36) in the Neonatal Chick.
  • Effect of Naloxone on the Anorexic Action by G1ucagon-Like Peptide-1 (7-36) in the Neonatal Chick

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It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether the endogenous opioid system contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of GLP-1 inhibited food intake over 2hr. However, the intraperitoneal injection of non-selective opiate antagonist, naloxone, did not influence the effect of intracerebroventricular administration of chicken GLP-1 (7-36) on feeding behavior. It is suggested that the anorexic effect of GLP-1 may not interact with endogenous opioids in the neonatal chick.

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