ラット,マウスおよびモルモットの成長に伴う心拍数および興奮伝導時間の変化

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  • Alteration in Heart Rate and Conduction Time During the Growing Process of Rats, Mice and Guinea Pigs

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In order to elucidate an aspect of the development of cardiac function during the growing process, heart rate and conduction time were measured in rats, mice and guinea pigs 1 to 90 days of age.<BR>1) The heart rates in rats and mice were almost stable within a range of 300 to 400 beats per minutes from birth to 5 days of age. Over a period from 14 to 30 days of age they increased temporarily to 530-620 beats per minute (in rats) and about 750 beats per minute (in mice). On the contrary, the heart rate in guinea pigs tended to decrease slightly with the advance in age.<BR>2) The PQ and QT intervals shortened in rats and mice and prolonged in guinea pigs with the advance in age after 5 days of age. They were correlated positively with the RR interval in these animals, except guinea pigs in which there was a relation between PQ and RR intervals.<BR>3) The QRS complex duration prolonged slightly in each animal species with the advance in age.<BR>4) In the mouse ECG, ST segment could not be discriminated even on the first day after birth. It shortened and disappeared in the rat ECG with the advance in age. On the contrary, it was recognized clearly in the guinea pig ECG throughout the growing stage and adulthood.

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