Melatonin Receptor in the Hen Hypothalamic and Median Eminence Areas: Demonstration of Presence and Changes in the Equilibrium Dissociation Constant and the Maximum Binding Capacity.

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  • 雌鶏の視床下部の視索前野領域および正中隆起部領域におけるメラトニン・レセプター：　その存在の立証と平衡解離定数ならびに最大結合容量の変動について
  • メンドリ ノ シショウカブ ノ シサク ゼンヤ リョウイキ オヨビ セイチュウ

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Using 3H-melatonin, radioligand binding assays were performed on membrane fractions of the hypothalamic tissues involving preoptic area and median eminence area of laying and non-laying hens. The binding was found to be specific for melatonin. By Scatchard analysis of saturation data, the value of the equilibrium dissociation constant obtained was of the order of nM, and the maximum binding capacity was of the order of fmol per mg protein. Both values changed during an ovulatory cycle or during a 24-h day with a different pattern between the two areas and between the laying and non-laying hens. The results suggest that there exists melatonin receptor in both preoptic and median eminence areas of the hypothalamus of the hen, and that the aspect of action of melatonin through binding to its receptor may be different between the two areas of the hypothalamus and between laying and non-laying hen.

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