Arterial Blood Pressure in Guinea Pigs with Congenitally Different Airway Sensitivity.

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  • KUWAHARA Masayoshi
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • YADA Hideaki
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • YAGI Yukihiro
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • AKITA Megumi
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • TODA Noriko
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • SUGANO Shigeru
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • NISHIBATA Ryoji
    Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
  • MIKAMI Hiroki
    Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
  • TSUBONE Hirokazu
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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  • 先天的に気道の感受性が異なったモルモットの血圧値

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Abstract

We investigated the characteristics of arterial blood pressures and heart rate (HR) in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs under conscious state. Arterial blood pressures (systolic blood pressure; SBP, mean blood pressure; MBP, diastolic blood pressure; DBP) were measured using a recently developed oscillometric device. The values of measurement parameters are as follows; BHS (HR: 253.5±5.1, SBP: 105.7±1.6, MBP: 75.1±1.9, DBP: 60.0±2.2) and BHR (HR: 253.7±4.2, SBP: 106.8±1.3, MBP: 72.7±1.6, DBP: 55.8±1.9). We could not observe any differences in arterial blood pressures and HR between these strains. These results suggest that airway hyperresponsiveness is not significantly affected on the cardiovascular functions under resting conditions.

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