プロゲステロン持続性投与の排卵抑制効果

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タイトル別名
  • Prolonged inhibitory effect of progesterone on ovulation in the domestic hen (Gallus domesticus).
  • プロゲステロン持続性投与の排卵抑制効果〔英文〕
  • プロゲステロン ジゾクセイ トウヨ ノ ハイラン ヨクセイ コウカ エイブン

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抄録

Progesterone in Silastic tubing (Pt) was implanted subcutaneously 1.5hr after the second (C2) ovulation of the sequence in the hen and effects of Pt treatment on subsequent ovula-tion and plasma concentrations of LH, progesterone (P4), testosterone (T) and estradiol (E2) were studied. Plasma concentrations of P4 increased rapidly about 5-fold and remained high throughout 45hr after Pt implantation. LH levels also significantly increased (1.4-fold) 4hr after Pt treatment but declined thereafter to levels below the pretreatment levels. T and E2 levels showed changes similar to LH levels but significant changes were detected only at 45 hr after the treatment. This treatment resulted in delayed ovulation for more than 41 hr. To examine the responsiveness of the hypothalamo-anterior pituitary-ovarian axis in those hens either ovine LH (100μg), synthetic [Arg8]-LHRH (25μg) or P4 (1.0mg) was injected at 45hr after Pt implantation. Both LH and LHRH injections induced ovulations at the rate of 70 and 80%, respectively. Conversely, P4 injection (after Pt treatment) failed in induc-ing ovulation in the majority of hens examined (ovulation, 27%). The same of ovine LH, LHRH and P4 induced ovulations at the rates of 70, 80 and 75%, respectively, when they were injected 13.5hr after C2 ovulation in hens without Pt treatment. These results sug-gest that exogenous Pt may exert its inhibitory effect on the hypothalamus or other regions of the CNS implicated with regulation of the preovulatory LH release. The ovulation-induc-tion time in hens pretreated with Pt was shorter in response to LH (6.0hr) or LHRH (4.7 hr) injection when compared to hens without Pt treatment (8.8hr). This was reflected upon higher concentrations of plasma P4 in Pt-treated hens.

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