卵胞刺激ホルモンによるウズラ顆粒膜細胞ZPC合成促進の細胞内情報伝達様式
書誌事項
- タイトル別名
-
- Signal Transduction of Follicle-Stimulating Hormone in the Production of ZPC-homologue in Cultured Quail Granulosa Cells.
この論文をさがす
説明
In a previous study, we found that follicle-stimulating hormone (FSH) promotes the production of ZPC-homologue in quail granulosa cells during culture. In order to evaluate the role of protein kinases in ZPC-homologue production, granulosa cells were cultured with FSH, dibutyryl cAMP or phorbol ester in the presence or absence of phosphodiesterase inhibitor, and the amount of ZPC-homologue production was then measured by radioactivity incorporation in proteins immunoprecipitated by anti ZPC-homologue antibody after incubation of the cells with [3H] leucine for 6hr. When the granulosa cells were incubated with FSH, ZPC-homologue production was increased in a dose-dependent manner. This effect was mimicked by dibutyryl cAMP, whereas phorbol ester had no such effect. Furthermore, phosphodiesterase inhibitor significantly potentiated FSH-stimulated ZPC-homologue production. These results demonstrate that quail granulosa cells in culture produce a ZPC-homologue when stimulated with FSH and that this process might be, at least in part, mediated by the intracellular signal transduction system involving adenylate cyclase and cyclic AMP.
収録刊行物
-
- 日本家禽学会誌
-
日本家禽学会誌 37 (5), 271-279, 2000
日本家禽学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681436145280
-
- NII論文ID
- 10009951955
-
- NII書誌ID
- AN00186755
-
- NDL書誌ID
- 5496697
-
- ISSN
- 00290254
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可