The Effects of Subcutaneous ANP Administration in Normal Canine
-
- KANNO Nobuyuki
- Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Miyazaki University
-
- ASANO Kazushi
- Laboratory of Veterinary, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
-
- TESHIMA Kenji
- Laboratory of Veterinary, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
-
- EDAMURA Kazuya
- Laboratory of Veterinary, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
-
- TANAKA Shigeo
- Laboratory of Veterinary, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Bibliographic Information
- Other Title
-
- 正常犬におけるヒト心房性ナトリウム利尿ペプチド皮下投与の効果
- セイジョウケン ニ オケル ヒト シンボウセイ ナトリウム リニョウ ペプチド ヒカ トウヨ ノ コウカ
Search this article
Abstract
The objective of our investigation was to evaluate the effectiveness of subcutaneous atrial natriuretic peptide (ANP) administration in normal dogs. We administrated subcutaneously recombinant ANP (25 μg/kg). Plasma ANP concentration rapidly increased and peak concentration of 591.5±143.0 pg/ml reached at 5 min after subcutaneous ANP administration. Area under the blood concentration time curve was 27,874 min·pg/ml and elimination half time was 18.9±3.7 min. Systolic blood pressure was decreased and urine volume was increased. However, electrolyte excretion was not significant change. Our results suggest that subcutaneous ANP administration had biological effects in normal dogs.
Journal
-
- Advances in Animal Cardiology
-
Advances in Animal Cardiology 43 (1), 1-6, 2010
Japanese Society of Veterinary Cardiology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282681436259968
-
- NII Article ID
- 10027947288
-
- NII Book ID
- AN10192925
-
- ISSN
- 18835260
- 09106537
-
- NDL BIB ID
- 11029684
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- IRDB
- NDL
- CiNii Articles
-
- Abstract License Flag
- Disallowed