Effects of Extracellular Products of Edwardsiella tarda on the Innate Immunity in Olive Flounder Paralichthys olivaceus
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- Lee Deok Chan
- Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University
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- Kim Do Hyung
- Department of Aqualife Medicine, College of Fisheries and Ocean Sciences, Chonnam National University
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- Park Soo Il
- Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University
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Abstract
Edwardsiella tarda causes a serious economic loss in olive flounder Paralichthys olivaceus farming industry. Extracellular products (ECP) of the pathogen contain various bio-molecules, some of which are responsible for the virulence. ECP of E. tarda virulent strain, KE-1, was used to investigate the effects on the nature of phagocytes isolated from olive flounder. High doses of ECP down-regulated phagocytosis and bactericidal activity on engulfed bacteria in phagocytes and chemiluminescence (CL) activity of macrophages. However, production of nitric oxide of macrophages soared under high concentrations of ECP. In contrast, low doses of ECP induced increases in bacterial invasion activity and CL activity. These results suggest that appropriate amounts of ECP could effectively stimulate cellular immunity, and that E. tarda ECP is a good candidate for vaccine adjuvant.
Journal
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- Fish Pathology
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Fish Pathology 45 (1), 17-23, 2010
The Japanese Society of Fish Pathology
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Keywords
Details 詳細情報について
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- CRID
- 1390282681436965888
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- NII Article ID
- 10026106027
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- NII Book ID
- AN00063165
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- ISSN
- 18817335
- 0388788X
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- NDL BIB ID
- 10633959
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed