書誌事項
- タイトル別名
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- Oral Immunization of Common Carp with a Liposome Vaccine Fusing Koi Herpesvirus Antigen
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抄録
In this study, we made liposome vaccines in which formalin-inactivated koi herpesvirus (KHV) was entrapped within the liposomal membrane compartment for oral vaccination in common carp Cyprinus carpio. In vaccination experiments, two fish groups (mean body weight, 30 g) received the liposome vaccine (protein concentration of 20 μg/mL using an isolate of NKC03 from Nara Prefecture or an isolate of IKC03 from Ibaraki Prefecture) at a dose of 20 μL/fish/day for 3 days. Neutralization titers of vaccinated fish sera were significantly higher than control at 22 days after last vaccination. In addition, 22 days after last vaccination, the fish were challenged with NKC03 at 102.3 TCID50/100 μL/fish or IKC03 at 102.2 TCID50/100 μL/fish by dropping the inoculum onto their gills, and resulted RPS was 74.4% and 65.0%, respectively. These results proved the efficacy of oral vaccination with the KHV liposome vaccine against KHV infection in carp.
収録刊行物
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- 魚病研究
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魚病研究 41 (4), 141-145, 2006
日本魚病学会
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詳細情報 詳細情報について
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- CRID
- 1390282681437775872
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- NII論文ID
- 10018654871
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- NII書誌ID
- AN00063165
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- COI
- 1:CAS:528:DC%2BD2sXitlCnsrw%3D
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- ISSN
- 18817335
- 0388788X
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- NDL書誌ID
- 8621280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可