A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum

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  • <i>Vibrio anguillarum</i> のキノロン耐性機構
  • Possible Mechanism of Quinolone Resistance in Vibrio anguillarum

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Abstract

To study a possible quinolone resistance mechanism in Vibrio anguillarum, we examined gyrA and parC mutations among the oxolinic acid-resistant strains and laboratory-derived mutants. One point mutation only in the quinolone resistance-determining region (QRDR) of the gyrA gene was detected in one strain isolated from ayu Plecoglossus altivelis and laboratory-derived mutants with low-level resistance. On the other hand, point mutations in both the gyrA and parC QRDRs were detected in one strain isolated from ayu and a laboratory-derived mutant with high-level resistance. These results suggest that as in other Gram-negative bacteria GyrA and ParC are the primary and secondary targets, respectively, of quinolone in V. anguillarum.

Journal

  • Fish Pathology

    Fish Pathology 41 (2), 73-75, 2006

    The Japanese Society of Fish Pathology

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