Therapeutic Efficacy of Oral Administration of Fosfomycin on Experimentally Induced Edwardsiellosis in Japanese Flounder

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  • Takano Tomokazu
    National Research Institute of Aquaculture, Fisheries Research Agency
  • Mizuno Yoshitsugu
    HimeSui Limited Liability Partnership
  • Fukuda Yutaka
    Fisheries Research Division, Oita Prefectural Agriculture, Forestry and Fisheries Research Center
  • Matsuyama Tomomasa
    National Research Institute of Aquaculture, Fisheries Research Agency
  • Sakai Takamits
    National Research Institute of Aquaculture, Fisheries Research Agency
  • Kato Goshi
    National Research Institute of Aquaculture, Fisheries Research Agency
  • Nakayasu Chihaya
    National Research Institute of Aquaculture, Fisheries Research Agency

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Abstract

Juvenile Japanese flounder Paralichthys olivaceus were immersion-challenged (2.0 × 106 CFU/mL, 60 min) with Edwardsiella tarda NUF806 strain. From the following day, diets containing fosfomycin (FOM) calcium were administrated orally at concentrations of 20, 40 or 80 mg potency/kg body weight/day for 6 consecutive days. Cumulative mortality of fish during the observation period of 21 days after the drug administration was significantly lower in all groups of FOM-treated fish than that in the control group. In addition, NUF806 strain and recent clinical isolates (n = 30) of E. tarda examined were all susceptible to FOM, with MIC of 2-4 μg/mL when estimated using the glucose-6-phosphate-containing Mueller-Hinton broth. The results suggest that FOM is a promising candidate for the treatment of edwardsiellosis in cultured Japanese flounder.

Journal

  • Fish Pathology

    Fish Pathology 50 (3), 123-126, 2015

    The Japanese Society of Fish Pathology

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