Alterations of the membrane composition induced by manganese depletion are late events in the nucleotide fermentation with Brevibacterium ammoniagenes ATCC 6782.

DOI
  • SCHMID Jan
    Institut fur Mikrobiologie der Universitdt Hannover Present address:, Department of Biology, University of Iowa
  • AULING Georg
    Institut fur Mikrobiologie der Universitdt Hannover

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説明

The general hypothesis of enhanced membrane permeability as a cause of increased production of primary and secondary metabolites (the "leak model") was disproved for the nucleotide (NAD) fermentation with Brevibacterium ammoniagenes ATCC 6872, as manganese deficient producer cells displayed a high membrane potential, like non-producing cells supplied with 10μM Mn2+.<br> However, the protein composition of the membrane was affected by a manganese deficiency. A manganese deficiency-like protein pattern of the membrane could be induced, in the presence of 10μM Mn2+, by either inhibition of DNA precursor biosynthesis (ribonucleotide reduction) with 20HIM hydroxyurea (HU) or inhibition of DNA replication with 30μM mi torn vein C.

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詳細情報 詳細情報について

  • CRID
    1390282681445535872
  • NII論文ID
    110006324403
  • NII書誌ID
    AA00515312
  • DOI
    10.1271/bbb1961.53.1783
  • ISSN
    18811280
    00021369
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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