Folimycin (concanamycin A) and Bafilomycin A1, Inhibitors Specific for V-ATPase, Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins.

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  • Folimycin (concanamycin A) and Bafilomycin A<sub>1</sub>, Inhibitors Specific for V-ATPase, Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins

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Both folimycin and bafilomycin A1, specific inhibitors of V-ATPase, blocked cell surface expression of viral envelope glyco-proteins without affecting their synthesis, but secretion of invertase was insensitive to both inhibitors. Invertase secreted in the presence of folimycin or bafilomycin A1 migrated faster than the control on electrophoresis. A significant difference was also detected among the two treatments, suggesting that the sites of their action are different.

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