Production of .BETA.-Thujaplicin in Cupressus lusitanica Suspension Cultures Fed with Organic Acids and Monoterpenes.

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  • ZHAO Jian
    Laboratory of Forest Chemistry and Biochemistry, Department of Forest Products Science, Faculty of Agriculture, Kyushu University Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
  • FUJITA Koki
    Laboratory of Forest Chemistry and Biochemistry, Department of Forest Products Science, Faculty of Agriculture, Kyushu University
  • SAKAI Kokki
    Laboratory of Forest Chemistry and Biochemistry, Department of Forest Products Science, Faculty of Agriculture, Kyushu University

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  • Production of β-Thujaplicin in Cupressus lusitanica Suspension Cultures Fed with Organic Acids and Monoterpenes
  • Production of ベータ Thujaplicin in Cupressus lusitanica Suspension Cultures Fed with Organic Acids and Monoterpenes

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Abstract

Effects of some organic acids and monoterpenes on production of β-thujaplicin were studied in Cupressus lusitanica suspension cultures. The fungal elicitor-induced biosynthesis of β-thujaplicin was promoted by the feedings of malate, pyruvate, fumarate, succinate, and acetate. These results suggest some relationships between acetate/pyruvate metabolism and β-thujaplicin biosynthesis, or between tricarboxylic acid cycle and β-thujaplicin biosynthesis. Feedings of C. lusitanica suspension cultures with some monoterpenes inhibited elicitor-triggered β-thujaplicin biosynthesis, but 2-carene and terpinyl acetate feedings significantly improved the β-thujaplicin production of C. lusitanica suspension cultures. These results indicate a possible involvement of terpinyl acetate and 2-carene in β-thujaplicin biosynthesis, as well as potential uses of these monoterpenes in large-scale β-thujaplicin production.

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