Metabolism of m-Tolyl N-Methylcarbamate (Tsumacide®) in Rats, Houseflies and Bean Plants

OHKAWA Hideo, YOSHIHARA Reiko, KOHARA Toshiko, MIYAMOTO Junshi

doi:10.1080/00021369.1974.10861283

書誌事項

タイトル別名

Metabolism of m-Tolyl N-Methylcarbamate (Tsumacide®) in Rats, Houseflies and Bean Plants

説明

The life of m-tolyl N-methylcarbamate (Tsumacide^®) in rat body is very short. Depending on the sex, from 78 to 96.6%, of an administered dose of ¹⁴C-Tsumacide is eliminated in the urine by 24hr after treatment. In rats, Tsumacide is mainly metabolized by oxidative reactions at m-methyl group and 4-position of the aromatic ring. Hydrolysis of the ester linkage occurs only to a minor extent. The resulting oxidation products and phenols are partly conjugated as sulfate and glucuronides. The major metabolic pathways are identical in male and female rats. From 78.7 to 85.8% of the radiocarbon is rapidly lost from the bean plants treated with ¹⁴C-Tsumacide and -Meobal by 24hr after treatment. Approximately 70% of the dose is also lost within 24hr after topical application of ¹⁴C-Tsumacide to houseflies. Oxidation of m-methyl group, N-methyl group and the aromatic ring at 4-position occurs with Tsumacide in houseflies and bean plants. Meobal undergoes hydroxylation at 4-methyl group and N-methyl group in bean plants. The oxidation products are conjugated as glucuronide and glucoside in houseflies and as glucosides in bean plants. Tsumacide metabolites formed by oxidation are less active than the original compound in anticholinesterase activity.

収録刊行物

Agricultural and Biological Chemistry

Agricultural and Biological Chemistry 38 (5), 1035-1044, 1974

公益社団法人日本農芸化学会

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詳細情報詳細情報について

CRID: 1390282681448080640

NII論文ID: 130003524633

DOI: 10.1271/bbb1961.38.1035; 10.1080/00021369.1974.10861283

COI: 1:CAS:528:DyaE2cXksleit7w%3D

ISSN: 18811280; 00021369

本文言語コード: en

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