Immunostimulatory Effects of a Polysaccharide-Rich Substance with Antitumor Activity Isolated from Black Currant (Ribes nigrum L.)
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- TAKATA Ryoji
- Mercian Corporation, Product Development Research Laboratory
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- YAMAMOTO Reiko
- Mercian Corporation, Product Development Research Laboratory
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- YANAI Takaaki
- Mercian Corporation, Product Development Research Laboratory
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- KONNO Tomonori
- Mercian Corporation, Product Development Research Laboratory
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- OKUBO Toshiyuki
- Mercian Corporation, Product Development Research Laboratory
Bibliographic Information
- Other Title
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- Immunostimulatory Effects of a Polysaccharide-Rich Substance with Antitumor Activity Isolated from Black Currant (<i>Ribes nigrum</i>L.)
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Description
The fruit juice of black currant was found to contain a polysaccharide-rich substance, which was designated cassis polysaccharide (CAPS), with macrophage-stimulating activity. Especially, its interleukin (IL)-1β-inducing activity was remarkably high, compared with other fruit juice preparations. CAPS was found to consist of rhamnose, mannose, arabinose, galactose, xylose, and glucose in a molar ratio of 11.3:0.9:54.1:29.8:2.0:1.9. CAPS turned out to be partitioned into a soluble component (CAPS-l.m.) and a precipitable component (CAPS-h.m.) with mean MWs of 80,000 and 600,000 respectively in 45% (v/v) ethanol solution. At least in vitro, CAPS-l.m. rather than CAPS-h.m. appeared to play an important role in macrophage activation. Oral administration of black currant juice and CAPS to Ehrlich carcinoma-bearing mice retarded the growth of the solid tumor by 45% and 51% respectively. CAPS administration had a stimulatory effect on the release of IL-2, IL-10, interferon-γ, and IL-4 from splenocytes in comparison with PBS treatment in tumor-bearing mice. The IL-4 level was, however, still lower than that exhibited by a group of normal mice. CAPS showed a certain cytotoxicity directly against tumor cells.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (11), 2042-2050, 2005
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681449501056
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- NII Article ID
- 130000030475
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- NII Book ID
- AA10824164
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- COI
- 1:STN:280:DC%2BD2MnisV2qsw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7728718
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed