Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes.
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- OGATA Shin
- Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University
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- TAKEUCHI Masayo
- Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University
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- FUJITA Hiroaki
- Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University
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- SHIBATA Katsumi
- Course of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture
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- OKUMURA Katsuzumi
- Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University
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- TAGUCHI Hiroshi
- Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University
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Description
In our previous study, we found that niacin-related compounds induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. We have investigated whether these compounds acted as inducers of apoptosis also in various other cell types. In human chronic myelogenous leukemia cells, K562, which are relatively resistant to various inducers of apoptosis, the apoptosis was induced by picolinic acid and dipicolinic acid in about 50% of the cells 5-10 mM via the caspase pathway, but was not at 1 mM. However, isonicotinamide did not induce apoptosis effectively in K562 cells. On the other hand, in normal human quiescent lymphocytes, the apoptosis was not induced by these compounds at the same concentrations. It is suggested that these compounds may induce apoptosis mainly in tumor cells. The change of intracellular peroxide levels was observed in the early phase of apoptosis induced by niacin-related compounds. We expect to make use of niacin-related compounds in the field of medicine.<br>
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 64 (6), 1142-1146, 2000
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681449782272
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- NII Article ID
- 110002680062
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- NII Book ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3cXks1Kqsbc%3D
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- ISSN
- 13476947
- 09168451
- http://id.crossref.org/issn/09168451
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- NDL BIB ID
- 5446246
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- PubMed
- 10923782
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed